MOTS-c 10mg: ≥99% Pure Mitochondrial-Derived Peptide for Research – Exercise-Mimetic & Metabolic Regulator
MOTS-c 10mg is a premium, laboratory-grade mitochondrial-derived peptide (MDP) with ≥99% purity (verified by HPLC and included Certificate of Analysis). Encoded in the mitochondrial 12S rRNA gene, this 16-amino-acid sequence (MRWQEMGYIFYPRKLR) functions as a key retrograde signaling molecule. In preclinical research, MOTS-c mimics exercise effects by activating AMPK, enhancing insulin sensitivity, promoting fatty acid oxidation, supporting mitochondrial biogenesis, and regulating metabolic homeostasis—without requiring physical activity.
Discovered in 2015, MOTS-c has been extensively studied in models of aging, obesity, type 2 diabetes, and age-related decline (PubMed studies 2015–2025). Researchers explore its potential in metabolic disorders, longevity pathways, NAFLD, osteoporosis, cardiovascular health, and inflammation modulation. All products at Peptide Basics are strictly for in vitro and laboratory research use only.
What is MOTS-c Peptide? – Structure, Mechanism & Research Significance
MOTS-c (CAS 1627580-64-6) is a naturally occurring mitochondrial-derived peptide that translocates to the nucleus under metabolic stress to influence gene expression. It operates primarily through the Folate-AICAR-AMPK pathway, boosting glucose uptake in skeletal muscle, increasing energy expenditure, reducing oxidative stress (ROS), and enhancing mitochondrial function. Studies show MOTS-c levels rise with exercise in humans and decline with age or metabolic dysfunction, positioning it as an “exercise mimetic” in research settings.
Key preclinical findings include:
- Improved physical performance and muscle homeostasis in young, middle-aged, and old models (Nature Communications, 2021).
- Protection against diet-induced obesity, insulin resistance, and fatty liver via enhanced fat oxidation and AMPK activation (Cell Metabolism, 2015).
- Anti-aging effects, including longevity pathway modulation and reduced inflammation.
- Potential in models of NAFLD, cardiovascular disease, osteoporosis, and even bacterial infection resistance.
For related mitochondrial and metabolic research peptides, explore our collection at Peptide Basics Peptides or check Humanin for complementary MDP studies.
MOTS-c 10mg Product Specifications – Research Grade
- Purity: ≥99% (HPLC verified, CoA provided)
- CAS Number: 1627580-64-6
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: 2174.6 Da
- Sequence: MRWQEMGYIFYPRKLR
- Form: Lyophilized white to off-white powder, 10mg in sterile glass vial
- Solubility: Fully soluble in bacteriostatic water
- Storage: –20°C for long-term; protect from light and moisture
- Shipping: Stable at room temperature for ≥4 weeks
Key Research Applications of MOTS-c (PubMed & Preclinical Insights 2015–2025)
Researchers use MOTS-c 10mg to investigate:
- AMPK activation and enhanced insulin sensitivity in metabolic models
- Exercise-like adaptations in skeletal muscle without training
- Increased fatty acid oxidation and protection from high-fat diet obesity
- Mitochondrial biogenesis, reduced ROS, and improved energy homeostasis
- Longevity and anti-aging mechanisms via nuclear gene regulation
- Potential therapeutic exploration in NAFLD, diabetic cardiomyopathy, osteoporosis, and inflammation
Buy MOTS-c for your lab today from Peptide Basics – fast US shipping, third-party tested purity, and dedicated research support.
Important Product Usage Warning – Research Use Only
This product is strictly for RESEARCH CHEMICAL USE ONLY (RUO). It is not approved for human consumption, veterinary use, or as a drug, food, or cosmetic. Bodily introduction into humans or animals is prohibited by law. Handle only in licensed laboratory settings by qualified professionals. Misbranding, misuse, or mislabeling is forbidden. All information is for educational purposes only.
NOT FOR HUMAN OR VETERINARY USE – RESEARCH USE ONLY
