SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide primarily investigated in cosmetic chemistry and dermatological research for its potential role in modulating skin topography, particularly in models of expression lines.1
Chemical Identity
- Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ (N-terminally acetylated octapeptide with C-terminal amidation).
- Molecular Formula: C₄₁H₇₀N₁₆O₁₆S.
- Molecular Weight: Approximately 1075.17 Da.
- CAS Number: 868844-74-0.
- It is structurally derived from Acetyl Hexapeptide-3 (Argireline) by extension with alanine and aspartic acid residues.1
Mechanism of Action (In Vitro / Ex Vivo Research Context)
SNAP-8 is studied as a competitive mimic of the N-terminal domain of SNAP-25 (Synaptosomal-Associated Protein 25), a key component of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor) complex.
In neuronal models:
- The SNARE complex (involving SNAP-25, syntaxin, and VAMP/synaptobrevin) facilitates synaptic vesicle docking and fusion with the presynaptic membrane.
- This enables release of neurotransmitters such as acetylcholine.
- By competing for binding sites on syntaxin and VAMP, SNAP-8 is hypothesized to destabilize or reduce the efficiency of SNARE complex formation.
- This may result in decreased neurotransmitter release, leading to reduced muscle contraction frequency and intensity in experimental skin models.2
Additional lines of research suggest possible interactions with dermal fibroblasts or contractile cells, potentially contributing to reduced micro-tension in tissue models. Synergistic effects with other peptides (e.g., Leuphasyl) or compounds like hyaluronic acid have also been explored in certain studies.2
