Mazdutide (IBI362) Peptide for Research – Strong Dual GLP-1/Glucagon Agonist

Mazdutide, also known as IBI362, is a synthetic peptide analog designed for in vitro and laboratory research investigating dual agonism of glucagon-like peptide-1 (GLP-1) and glucagon receptors. As a once-weekly research compound, mazdutide has been examined in preclinical and clinical trial settings for its effects on metabolic pathways, energy expenditure, appetite regulation, and body composition in research models of obesity and type 2 diabetes.

In various phase 2 and phase 3 studies (including GLORY, DREAMS, and high-dose trials), mazdutide has demonstrated dose-dependent outcomes in research contexts, including substantial reductions in body weight (up to ~20-21% in select high-dose cohorts at 20 weeks), waist circumference, liver fat content, and improvements in lipid profiles, blood pressure, and glycemic markers like HbA1c.

Key Research Findings on Mazdutide (IBI362)

• Weight Reduction in Research Models: Clinical trial data indicate dose-dependent body weight decreases, with mean reductions of 10-14% at standard doses (e.g., 4-6 mg) over 32-48 weeks, and up to 18-21% at higher doses (e.g., 9-16 mg cohorts) in obesity-focused studies. Significant proportions of research subjects achieved ≥15-20% weight loss.
• Metabolic and Lipid Improvements: Research shows reductions in waist circumference (up to 17%), serum lipids (LDL, triglycerides, total cholesterol), blood pressure, serum uric acid, and liver fat content (over 80% reduction in high-baseline models).
• Glycemic Control in Diabetes Models: Superior HbA1c reductions (e.g., -1.5% to -2.15%) compared to placebo or comparators like dulaglutide/semaglutide in head-to-head trials (e.g., DREAMS-3), with higher proportions achieving HbA1c <7.0% alongside ≥10% weight loss.
• Mechanism of Action in Lab Settings: Dual agonism combines GLP-1-mediated appetite regulation with glucagon receptor activation to increase energy expenditure, offering a differentiated profile from single-agonist compounds in metabolic research.

For more on related research peptides, visit our Peptides Overview or explore GLP-1 Research Compounds.

Why Research Mazdutide at Peptide Basics?

Peptide Basics supplies high-purity mazdutide for qualified laboratory use. All compounds are intended strictly for research and experimentation. Browse additional products like other metabolic peptides or visit our homepage for full catalog and resources.