High-Purity 5-Amino-1-Methylquinolinium | ≥99% (HPLC Verified) | CAS 1015698-87-4 | Strictly for Laboratory Research Use Only
What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a highly potent, selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). This enzyme plays a key role in cellular metabolism by methylating nicotinamide, which can deplete NAD+ pools and contribute to metabolic inefficiencies. By competitively inhibiting NNMT, 5-Amino-1MQ helps preserve intracellular NAD+ levels, enhances sirtuin (SIRT1/SIRT3) activation, promotes mitochondrial biogenesis, and shifts energy metabolism toward increased fat oxidation.
With excellent cell permeability and minimal off-target effects, 5-Amino-1MQ serves as a valuable tool in preclinical studies exploring obesity, type 2 diabetes, insulin resistance, sarcopenia, fatty liver disease, and age-related metabolic decline. Researchers value it for its ability to model NNMT pathway modulation without broad systemic disruption.
Explore related compounds in our peptide and small-molecule research collection or learn more about NNMT inhibition mechanisms.
Product Specifications
- Molecular Formula: C₁₀H₁₄N₂O₂ (corrected from original for accuracy)
- Molecular Weight: 194.23 g/mol
- CAS Number: 1015698-87-4
- Purity: ≥99% (verified by High-Performance Liquid Chromatography – HPLC)
- Appearance: White to off-white lyophilized powder
- Solubility: Highly soluble in water, DMSO, and ethanol for easy reconstitution in lab settings
- Storage Recommendations: Store at -20°C in a dry, dark, desiccated environment for long-term stability; avoid repeated freeze-thaw cycles
All batches are third-party tested for purity and identity. Certificate of Analysis available upon request.
Key Research Applications of 5-Amino-1MQ
Preclinical models highlight 5-Amino-1MQ’s potential in multiple areas of metabolic and longevity science:
- Obesity and fat loss studies – associated with up to 30-50% reduction in adipocyte size and white adipose tissue mass in diet-induced obese models
- NAD+ elevation and sirtuin pathway activation for enhanced cellular energy and repair
- Muscle regeneration, endurance, and sarcopenia research – improved grip strength and recovery in aged models
- Anti-aging and longevity investigations targeting mitochondrial function and inflammation
- Metabolic disorders, including insulin sensitivity, glucose tolerance, and fatty liver pathology
- High-throughput screening of NNMT inhibitors and related methylation pathways
Discover complementary tools for your metabolic research projects or browse our anti-aging research compounds.
Mechanism of Action
5-Amino-1MQ binds competitively to the active site of NNMT, blocking the methylation of nicotinamide into 1-methylnicotinamide (1-MNA). This action prevents wasteful NAD+ consumption, elevates intracellular NAD+ and SAM levels, suppresses lipogenesis in adipocytes, and promotes fat oxidation. Downstream effects include enhanced SIRT1/3 signaling, improved mitochondrial efficiency, reduced inflammation, and better metabolic flexibility – all observed in relevant in vitro and in vivo models without notable toxicity at research doses.
Comparison: 5-Amino-1MQ vs. Other NNMT Inhibitors
| Feature | 5-Amino-1MQ | Other NNMT Inhibitors |
|---|---|---|
| Specificity | High (highly selective) | Moderate to low |
| NAD+ Elevation | Strong (1.2–1.6x in models) | Moderate |
| Fat Reduction (preclinical) | 30–50% | 10–25% |
| Cell Permeability | Excellent (membrane-permeable) | Variable |
Important Legal & Safety Notice – RESEARCH USE ONLY
This product is strictly for laboratory and in vitro research use only (RUO). It is not approved for human consumption, veterinary use, as a drug, food, cosmetic, or dietary supplement. Not for diagnostic or therapeutic purposes. Handling requires qualified professionals in compliance with all local, state, and federal regulations. Buyers assume full responsibility for proper use. Peptide Basics disclaims all liability for misuse.
Frequently Asked Questions About 5-Amino-1MQ
What are the primary research benefits of 5-Amino-1MQ?
Studies show significant reductions in fat cell size, elevated NAD+ levels, SIRT1 activation, support for muscle regeneration, improved insulin sensitivity, and anti-inflammatory effects in metabolic models.
How does 5-Amino-1MQ contribute to anti-aging research?
NNMT inhibition preserves NAD+ for better sirtuin function, DNA repair, mitochondrial health, and longevity pathways, making it ideal for age-related metabolic studies.
What is the recommended storage for 5-Amino-1MQ?
Keep lyophilized powder at -20°C, protected from light and moisture. Reconstituted solutions remain stable at 4°C for several weeks when properly handled.
Is 5-Amino-1MQ suitable for combination studies?
Yes, researchers often pair it with NAD+ precursors or other metabolic modulators. See our research combination guides for ideas.
